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Sanctum

37 Games with a sci-fi setting like Sanctum that you should try

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We filtered the 50 games similar to Sanctum down to the 37 that fit the “Sci-Fi” category. Iron Grip: Warlord, DOOM 3 and Zombie Panic! Source top the list, ranked by affinity and similarity score to Sanctum.

NextGameLike72/ 100

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GenreShooterSubgenreFPS
Tags
CasualSoloMultiplayer
Year 2011Dev Coffee Stain Studios
Stores

Quick answer

Within the “Sci-Fi” category, the closest game to Sanctum is Iron Grip: Warlord — scoring 84/100 on our similarity scale. DOOM 3 and Zombie Panic! Source follow close behind.

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The best games with a sci-fi setting like Sanctum

37 similar games foundUpdated May 2026

Handpicked by our similarity algorithm, these are the titles with the highest gameplay match to Sanctum. Each one has been evaluated across 12 real attributes — from combat style and progression mechanics to world structure and visual perspective — so every recommendation is based on how the game actually plays, not just its genre label.

1

Iron Grip: Warlord

84
NGL76
Iron Grip: Warlord
Closest overall match
ShooterFPS
Co-opSoloMultiplayerMeleeRangedSci-FiFirst Person
Year 2008Dev ISOTXPlaytime ~1hOn PC

Shelved next to Sanctum for good reason: melee combat, a sci-fi setting and co-op play. Both also lean on a first-person view. The distance is in setting and visuals — its own ground is fantasy world and an isometric view.

Genre100Combat100Game mode92Visuals67Setting64
2

DOOM 3

78
NGL85
DOOM 3
Closest on visuals
ShooterFPS
SoloMultiplayerCo-opMeleeRangedSci-FiFirst Person
Year 2004Dev id Software · Bethesda SoftworksPlaytime ~1hOn PC · PS · Xbox

It shares the essentials of what Sanctum does: melee combat, a sci-fi setting and single-player focus. Both also lean on a first-person view. The distance is in tone and setting — its own ground is dark, oppressive atmosphere and horror setting.

Genre100Combat100Visuals100Game mode92Setting55Tone0
3

Zombie Panic! Source

75
NGL73
Zombie Panic! Source
ShooterFPS
MultiplayerCo-opOnlineMeleeRangedCasualSci-FiFirst Person
Year 2008Dev Zombie Panic TeamPlaytime ~1hOn PC

What brings it close to Sanctum is a casual, approachable feel, melee combat and a sci-fi setting, and the two track each other on genre, combat and visuals. The common ground extends to a first-person view and multiplayer gameplay. Where the two diverge is setting and tone: dark, oppressive atmosphere and horror setting.

Genre100Combat100Visuals100Game mode91Tone69Setting57
4

Killing Floor

72
NGL77
Killing Floor
Closest on game mode
ShooterFPS
Co-opSoloMultiplayerOnlineRangedMeleeSci-FiFirst Person
Year 2009Dev Tripwire InteractivePlaytime ~5hOn PC · Apple Macintosh · Linux

Shelved next to Sanctum for good reason: ranged combat, a sci-fi setting and co-op play. To that it adds a first-person view. They part company on tone and setting: this one brings dark, oppressive atmosphere and horror setting.

Genre100Combat100Game mode100Visuals86Setting43Tone0
5

Broforce

72
NGL85
Broforce
Closest on setting
ShooterFPS
MultiplayerCo-opSoloMeleeRangedCasualSci-Fi
Year 2015Dev Devolver DigitalPlaytime ~6hOn PC · PS · Apple Macintosh

The thread back to Sanctum runs through a casual, approachable feel, melee combat and a sci-fi setting. Both also lean on single-player focus. The distance is in visuals — its own ground is pixel art.

Released 4 years after Sanctum.

Genre100Combat100Setting100Tone85Game mode77Visuals0
6

Lost Planet 2

69
NGL68
Lost Planet 2
ShooterFPS
Co-opSoloMultiplayerOnlineMeleeSci-Fi
Year 2010Dev CapcomOn PlayStation 3 · Linux · PC

Genre puts it alongside Sanctum, and so does melee combat, a sci-fi setting and co-op play. The distance is in visuals and combat — its own ground is a third-person camera.

Genre100Game mode100Setting100Combat60Visuals0
7

Quake II

68
NGL89
Quake II
ShooterFPS
SoloMultiplayerCo-opRangedMeleeSci-FiFirst Person
Dev Head Games PublishingOn PC

If Sanctum worked for you because of ranged combat, a sci-fi setting and single-player focus, the same is here. The common ground extends to a first-person view. Where the two diverge is tone and setting: dark, oppressive atmosphere and horror setting.

Genre100Combat100Visuals100Game mode91Setting65Tone0
8

Serious Sam HD: The Second Encounter

67
NGL86
Serious Sam HD: The Second Encounter
ShooterFPS
SoloMultiplayerCo-opOnlineMeleeSci-FiFirst Person
Year 2010Dev Croteam · Devolver DigitalOn Linux · PC

On paper it is what Sanctum is — melee combat, a sci-fi setting and single-player focus — though the resemblance is mostly at that level. The common ground extends to a first-person view. Where the two diverge is tone and combat: dark, oppressive atmosphere.

Genre100Game mode100Setting100Visuals73Combat59Tone0
9

Portal 2

67
NGL96
Portal 2
ShooterFPS
Co-opSoloMultiplayerMeleeRangedSci-FiFirst Person
Year 2011Dev Valve Software · Electronic ArtsPlaytime ~11hOn PC · PS · Xbox

If Sanctum worked for you because of melee combat, a sci-fi setting and co-op play, the same is here. To that it adds a first-person view. They part company on tone: this one brings strong narrative focus.

Genre100Combat100Setting100Visuals100Game mode73Tone0
10

Aliens vs. Predator

66
NGL76
Aliens vs. Predator
ShooterFPS
SoloMultiplayerCo-opMeleeRangedSci-FiFirst Person
Year 2010Dev SEGAPlaytime ~3hOn PC · PS · Xbox

On paper it is what Sanctum is — melee combat, a sci-fi setting and single-player focus — though the resemblance is mostly at that level. The common ground extends to a first-person view. Where the two diverge is tone and setting: dark, oppressive atmosphere and horror setting.

Genre100Visuals100Game mode92Combat83Setting64Tone0
11

Prey

66
NGL79
Prey
ShooterFPS
SoloMultiplayerMeleeRangedSci-FiFirst Person
Year 2006Dev Human Head Studios · SkyZone EntertainmentOn Linux · PC · Mac

It shares the essentials of what Sanctum does: melee combat, a sci-fi setting and single-player focus. The common ground extends to a first-person view. Where the two diverge is game mode: puzzle design.

Genre100Combat100Setting100Visuals100Game mode62
12

Borderlands 4

66
NGL72
Borderlands 4
ShooterFPS
SoloMultiplayerCo-opSci-FiFirst Person
Year 2025Dev Gearbox Software · 2KOn Xbox · Switch · PC

It shares the essentials of what Sanctum does: a sci-fi setting, single-player focus and a first-person view. Its own ground is deep RPG systems.

Released 14 years after Sanctum.

Genre100Setting100Visuals100Game mode91
13

Ratchet: Deadlocked

66
NGL70
Ratchet: Deadlocked
ShooterFPS
SoloMultiplayerCo-opSci-FiFirst Person
Year 2005Dev Insomniac Games · Sony Computer Entertainment

The thread back to Sanctum runs through a sci-fi setting, single-player focus and a first-person view. What it adds of its own: exploration and discovery, and precision platforming.

Genre100Setting100Game mode91Visuals72
14

Descent

65
NGL88
Descent
ShooterFPS
SoloMultiplayerCo-opMeleeSci-FiFirst Person
Year 1994Dev Parallax Software · SoftBankOn PC · Mac

The genre is the same as Sanctum’s, and with it melee combat, a sci-fi setting and single-player focus. The common ground extends to a first-person view. Where the two diverge is combat and setting: a space setting.

It predates Sanctum by 17 years, with what that implies technically.

Genre100Visuals100Game mode91Setting64Combat55
15

Astro Duel 2

65
NGL90
Astro Duel 2
ShooterFPS
MultiplayerSoloCo-opRangedMeleeSci-Fi
Year 2024Dev Rusty Moyher · Wild RoosterOn PC · Apple Macintosh · Nintendo

Shelved next to Sanctum for good reason: ranged combat, a sci-fi setting and multiplayer gameplay. They part company on visuals and setting: this one brings a cyberpunk setting and offline play.

Released 13 years after Sanctum.

Genre100Combat100Game mode57Setting51Visuals0

More similar-games lists to keep going

Found one on the list you already love? Open its own list: the games that play most like it, ranked, with the reason for each.

Explore games similar to Sanctum by category

If Sanctum left you wanting more, this is where you narrow it down. Was it the casual or the sci-Fi that hooked you? There is a list of just that. And if you play on PS5, PlayStation and Xbox, filter by platform and skip the games you could not play anyway.

Rankings in the same genre

Sometimes what you want is not a Sanctum look-alike but simply the best FPS Games there are. That is what these rankings are for: no comparison to anything, just the highest-rated games. And if you feel like widening the net, the Shooter Games ranking is a good way to run into something you were not expecting.